Journal
JOURNAL OF NATURAL PRODUCTS
Volume 75, Issue 8, Pages 1436-1440Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np300270p
Keywords
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Funding
- NIH through the Fogarty International Center [ICBG 5U01T006671]
- NIH [RR06262]
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As part of our screening for anti-HIV agents from marine invertebrates, the MeOH extract of Didemnum molle was tested and showed moderate in vitro anti-HIV activity. Bioassay-guided fractionation of a large-scale extract allowed the identification of two new cyclopeptides, mollamides E and F (1 and 2), and one new tris-phenethyl urea, molleurea A (3). The absolute configurations were established using the advanced Marfey's method. The three compounds were evaluated for anti-HIV activity in both an HIV integrase inhibition assay and a cytoprotective cell-based assay Compound 2 was active in both assays with IC50 values of 39 and 78 mu M, respectively. Compound 3 was active only in the cytoprotective cell-based assay, with an IC50 value of 60 mu M.
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