Journal
JOURNAL OF NATURAL PRODUCTS
Volume 75, Issue 9, Pages 1595-1602Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np300404f
Keywords
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Funding
- NSFC [30930109]
- National Key Innovation Project [2009ZX09501-014, 2011AA090701]
- ICP [2010DFA31610]
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Twelve new eunicellin-based diterpenoids, astrogorgins B-M (1-12), were isolated from a Chinese gorgonian Astrogorgia sp., together with ophirin, muricellin, astrogorgin, calicophirins A and B, and 14-deacetoxycalicophirin B. The structures of the new compounds were elucidated by extensive spectroscopic analysis and by comparison with data reported in the literature. Significant antifouling activity was observed for 14-deacetoxycalicophirin B against the larval settlement of the barnacle Balanus amphitrite at nontoxic concentrations with an EC50 = 0.59 mu g/mL, while the other analogues were effective within an EC50 range of 5.14-17.8 mu g/mL.
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