Journal
JOURNAL OF NATURAL PRODUCTS
Volume 75, Issue 5, Pages 935-941Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np300103w
Keywords
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Funding
- National Natural Science Foundation of China [41130858, 40976077, 30901879, 41176121, 81172977]
- Ministry of Education of China [NCET- 11-0472, 20090132110002]
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Chemical investigation of a marine-derived fungus Nigrospora sp., isolated from an unidentified sea anemone, yielded two new hydroanthraquinone analogues, 4a-epi-9 alpha-methoxydihydrodeoxybostrycin (1) and 10-deoxybostrycin (2), together with seven known anthraquinone derivatives (3-9). The structures of the two new compounds were established through extensive NMR spectroscopy as well as a single-crystal X-ray diffraction analysis using Cu K alpha radiation. The antibacterial activities of compounds 1-9 and 10 acetyl derivatives (6a, 7a, 8a-8g, 9a) were evaluated in vitro. Compound 6a, the acetylated derivative of 6, exhibited promising activity against Bacillus cereus with an MIC value of 48.8 nM, which was stronger than that of the positive control ciprofloxacin (MIC = 1250 nM). Analysis of the antibacterial screening data for the metabolites and their acetyl derivatives revealed the key structural features required for this activity.
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