Journal
JOURNAL OF NATURAL PRODUCTS
Volume 75, Issue 10, Pages 1824-1827Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np300580z
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Funding
- Scripps Institution of Oceanography, San Diego, CA, USA
- National Science Foundation [CHE-0722319]
- Murdock Charitable Trust [2005265]
- OSU College of Pharmacy
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The CH2Cl2 MeOH extract of a South African tunicate described as the new Synoicum globosum Parker-Nance sp. nov. (Ascidiacea, Aplousobranchia) was subjected to H-1 NMR-guided fractionation. This resulted in the identification of new 3-bromorubrolide F (1), 3'-bromorubrolide E (2), 3'-bromorubrolide F (3), and 3',3 ''-dibromorubrolide E (4) and reisolation of known rubrolides E (5) and F (6), based on NMR spectroscopic and mass spectrometric data. Biological testing of both new and known members of this reported antimicrobial family of halogenated, aryl-substituted furanones indicated moderate antibacterial properties for 3'-bromorubrolide E (2), 3',3 ''-dibromorubrolide E (4), and rubrolide F (6) against methicillin-resistant Staphylococcus aureus (MRSA) and S. epidermidis.
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