Journal
JOURNAL OF NATURAL PRODUCTS
Volume 75, Issue 4, Pages 834-851Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np200993k
Keywords
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Funding
- National Center for Complementary and Alternative Medicine (NCCAM) [RC2 AT005899]
- Office of Dietary Supplements [P50 AT000155]
- United States Pharmacopeial Convention, Inc
- National Institutes of Health (NIH)
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Covering the literature from mid-2004 until the end of 2011, this review continues a previous literature overview on quantitative H-1 NMR (qHNMR) methodology and its applications in the analysis of natural products. Among the foremost advantages of qHNMR is its accurate function with external calibration, the lack of any requirement for identical reference materials, a high precision and accuracy when properly validated, and an ability to quantitate multiple analytes simultaneously. As a result of the inclusion of over 170 new references, this updated review summarizes a wealth of detailed experiential evidence and newly developed methodology that supports qHNMR as a valuable and unbiased analytical tool for natural product and other areas of research.
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