Journal
JOURNAL OF NATURAL PRODUCTS
Volume 75, Issue 4, Pages 774-778Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np2009016
Keywords
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Funding
- National Natural Science Foundation of China [81072573, 81172978, 41106127, 81001394]
- Major Program of Modernization of Chinese Medicine (STCSM) [STCSM, 09dZ1975800]
- NIH
- NIAID
- Division of AIDS [AI 27094]
- USDA [58-6408.2-0009]
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Four new alkaloids, (-)-8'-oxo-agelasine D (2), ageloxime B (3), (+)-2-oxo-agelasidine C (4), and 4-bromo-N-(butoxymethyl)-1H-pyrrole-2-carboxamide (5), and the known compound (-)-ageloxime D (1) were isolated from the marine sponge Agelas mauritiana. Their chemical structures were established on the basis of spectroscopic analysis. Compounds 1 and 3 both showed antifungal activity against Cryptococcus neoformans and antileishmanial activity against Leishmania donovani in vitro. Compound 3 also exhibited antibacterial activity against Staphylococcus aureus and methicillin-resistant S. aureus in vitro.
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