Journal
JOURNAL OF NATURAL PRODUCTS
Volume 75, Issue 2, Pages 148-152Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np2006742
Keywords
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Funding
- Ministry of Science and Technology [2011AA09070110, 2010CB833802]
- Natural Science Foundation of China [30970293, 30910103914]
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Bioassay-guided fractionation of the culture extract of Aspergillus wentii EN-48, an endophytic fungus isolated from an unidentified marine brown algal species of the genus Sargassum, led to the isolation of three new tetranorlabdane diterpenoids, asperolides A-C (1-3), and five related derivatives (4-8). The structures of these compounds were established on the basis of spectroscopic interpretation, and compound 1 was confirmed by X-ray crystallographic analysis. The absolute configuration of I was determined by application of the modified Mosher's method. An Xray structure for wentilactone B (6) is also reported. Compounds 1-8 were evaluated for cytotoxic and antibacterial activities.
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