Journal
JOURNAL OF NATURAL PRODUCTS
Volume 75, Issue 2, Pages 181-188Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np200759h
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Funding
- NIMH
- Lynde and Harry Bradley Foundation
- NIDA-NRL [Y1-DA1101]
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The development of an efficient diastereoselective method that permits rapid construction of the tetracyclic core 17 of the Strychnos-Aspidosperma alkaloids is described. Enaminone 16, synthesized in high yield, has been cyclized under the influence of a Bronsted acid to provide the core tetracyclic framework 17 of the Strychnos alkaloids in optically active form or alternatively to the beta-ketoester tetrahydro-beta-carboline (THBC) unit 18, by varying the equivalents of acid and the molar concentration. Attempts to utilize 18 to form the C(7)-C(16) bond of the akuammiline related alkaloids represented by strictamine (22), using metal-carbenoid chemistry, are also described.
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