Journal
JOURNAL OF NATURAL PRODUCTS
Volume 75, Issue 11, Pages 1937-1943Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np300505y
Keywords
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Funding
- Chinese Academy of Sciences for Key Topics in Innovation Engineering [KZCX2-YW-JC202, KSCX2-EW-G-12]
- Ministry of Science and Technology of China [2012AA092104, 2010CB833805]
- National Science Foundation of China [41006089, 41106143, 31125001]
- Natural Science Funds of South China Sea Institute of Oceanology for Young Scholar [SQ200903]
- Chinese Academy of Sciences [08SL111002]
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The strain SCSIO N160 was isolated from a South China Sea sediment sample and was characterized as a Micromonospora rosaria species on the basis of its 16S rRNA gene sequence. Three new fluostatins, I-K (1-3), were isolated from the culture of M rosaria SCSIO N160, together with six known compounds, fluostatins C-F (4-7), rabelomycin (8), and phenanthroviridone (9). The structure of fluostatin D (5) was confirmed by an X-ray crystallographic study. The absolute configuration of 1 and 3 was assigned by electronic circular dichroism calculations. Compounds 8 and 9 exhibited good antimicrobial activities against Staphylococcus aureus ATCC 29213 with MIC values of 1.0 and 0.25 mu g/mL, respectively. Compound 9 also exhibited significant in vitro cytotoxic activities toward SF-268 (IC50 0.09 mu M) and MCF-7 (IC50 0.17 mu M).
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