Journal
JOURNAL OF NATURAL PRODUCTS
Volume 75, Issue 2, Pages 290-294Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np2009187
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Funding
- Mitsubishi Foundation
- University of Tokyo (Center for Medical System Innovation)
- Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan
- Grants-in-Aid for Scientific Research [23710250] Funding Source: KAKEN
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Cyclic peptides containing 5-hydroxytryptophan and thiazole moieties were isolated from the marine sponge Discodermia calyx collected near Shikine-jima Island, Japan. The structures of calyxamides A (1) and B (2), including the absolute configurations of all amino acids, were elucidated by spectroscopic analyses and degradation experiments. The structures are similar to keramamides F and G, previously isolated from Theonella sp. The analysis of the 16S rDNA sequences obtained from the metagenomic DNA of D. calyx revealed the presence of Canclidatus Entotheonella sp., an unculturable fi-proteobacterium inhabiting the Theonella genus and implicated in the biosynthesis of bioactive peptides.
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