Journal
JOURNAL OF NATURAL PRODUCTS
Volume 75, Issue 6, Pages 1215-1219Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np300152d
Keywords
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Funding
- Chinese Academy of Sciences [KZCX2-YW-JC202, KZCX2-EW-G-12, 08SL111001]
- Science and Technology Planning Project of Guangdong Province [2010B030600010]
- National High Technology Research Program of China [2012AA092104]
- National Basic Research Program of China [2010CB833805]
- Scientific Research Foundation for the Returned Overseas Chinese Scholars of the State Education Ministry
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Three new cycloheptapeptides, cordyheptapeptides C-E (1-3), were isolated from the fermentation extract of the marine-derived fungus Acremonium persicinum SCSIO 115. Their planar structures were elucidated on the basis of extensive MS, as well as 1D and 2D (COSY, HMQC, and HMBC) NMR spectroscopic data analyses. The absolute configurations of the amino acid residues were determined by single-crystal X-ray diffraction, Marfey's method, and chiral-phase HPLC analysis. Compounds 1 and 3 displayed cytotoxicity against SF-268, MCF-7, and NCI-H460 tumor cell lines with IC50 values ranging from 2.5 to 12.1 mu M.
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