Journal
JOURNAL OF NATURAL PRODUCTS
Volume 75, Issue 12, Pages 2178-2182Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np3006277
Keywords
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Funding
- British Columbia Lung Association
- Canadian Institute of Health Research [MOP-82855]
- NSERC
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Four butenolides, ramariolides A-D (1-4), have been isolated from the fruiting bodies of the coral mushroom Ramaria cystidiophora. Their structures were elucidated by analysis of ID and 2D NMR data and a single-crystal X-ray diffraction analysis of 1, and their absolute configurations were established using Mosher's method. The major metabolite, ramariolide A (1), which contains an unusual spiro oxiranebutenolide moiety, showed in vitro antimicrobial activity against Mycobacterium smegmatis and Mycobacterium tuberculosis.
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