Journal
JOURNAL OF NATURAL PRODUCTS
Volume 75, Issue 4, Pages 527-530Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np300051k
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Funding
- NIH [GM052964, T32 CA009523]
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De novo synthesis of the natural products benzosceptrin C (7) and nagelamide H (8) was achieved using cell-free enzyme preparations from the marine sponges Agelas sceptrum and Stylissa caribica employing synthetic 7-N-15-oroidin. These, studies provide direct experimental evidence to support the long-standing, but untested, hypothesis that oroidin is a precursor to more complex pyrrole-aminoimidazole alkaloids, such as the sceptrins, benzosceptrins, and nagelamides. In addition, a new nagelamide, didebromonagelamide A (5b), was isolated from S. caribica, representing the first report of a nagelamide-like compound from the Caribbean.
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