Journal
JOURNAL OF NATURAL PRODUCTS
Volume 74, Issue 10, Pages 2261-2264Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np100872k
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Funding
- University of Malaya [J-00000-73552]
- Ministry of Science Technology and Innovation, Malaysia
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A methanol-soluble extract of the bark of Myristica cinnamomea was found to exhibit anti-quorum sensing activity, and subsequent bioassay-guided isolation led to the identification of the active compound malabaricone C (1). Compound 1 inhibited violacein production by Chromobacterium violaceum CV026 when grown in the presence of a cognate signaling molecule, N-3-oxohexanoyl-homoserine lactone. Furthermore, 1 inhibited the quorum sensing-regulated pyocyanin production and biofilm formation in Pseudomonas aeruginosa PAO1. These results suggest that the anti-quorum sensing activity of 1 and related molecules should be investigated further.
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