Journal
JOURNAL OF NATURAL PRODUCTS
Volume 74, Issue 4, Pages 796-802Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np100851s
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Funding
- National Science Council of Republic of China
- Taiwan Department of Health Cancer Research Center of Excellence [DOH100-TD-B-111-004]
- NIH [CA17625]
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Two new saponins, panajaponol (1) and pseudoginsenoside RT1 butyl ester (2), together with 35 known compounds (3-37), were isolated from the roots. of Panax japonicus var. major. The structures of :1 and 2 were elucidated on the basis of spectroscopic analysis and chemical methods. Furthermore, a LC-MS/MS method was developed for confirming 2, 3, :and, 8 as natural compounds containing a butyl ester group: This method should be useful for. distinguishing, between minor natural and artifactual compounds in panax species. Moreover, compounds 3, 6, 8, 9, 11, 13, and 15 exhibited strong inhibition of superoxide anion generation and elastase release by human neutrophils in response to formyl-L-methionyl-L-leucyl-L-phenylalanine/cytoc B (fMLP/CB), with IC50 values ranging from 0.78 to 43.6 mu M. In addition, 1 showed greater than 2- to 3-fold selective cytotoxic activity against KB and DU145 cancer cell lines.
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