Journal
JOURNAL OF NATURAL PRODUCTS
Volume 74, Issue 9, Pages 2005-2009Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np2004209
Keywords
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Funding
- National Museum of Marine Biology Aquarium
- National Science Council, Taiwan [NSC 100-2320-B-291-001, NSC 98-2320-B-291-001-MY3]
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One novel C-21 terpenoidal natural product, ircinolin A (2), two new C-22 furanoterpene metabolites, 15-acetylirciformonin B (3) and 10-acetylirciformonin B (4), and two known compounds, irciformonin B (1) and irciformonin F (5), were isolated from the sponge Ircinia sp. The structures of these compounds were elucidated on the basis of their spectroscopic data. Moreover, the absolute configuration of 1 was determined by Mosher's method. Among these metabolites, 2 is the first C-21 terpenoid-derived metabolite to be reported from this genus. Compounds 1 and 3-5 exhibited significant cytotoxic activity against K562, DLD-1, HepG2, and Hep3B cancer cell lines.
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