Journal
JOURNAL OF NATURAL PRODUCTS
Volume 74, Issue 9, Pages 1965-1971Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np200470u
Keywords
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Funding
- Egyptian Government
- SULSA postdoctoral fellowship
- Leverhulme Trust
- Royal Society [JP100654]
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The metabolic profile of Streptomyces sp. strain C34, isolated from the Chilean hyper-arid Atacama Desert soil, is dependent on the culture media used for its growth. The application of an OSMAC approach on this strain using a range of cultivation media resulted in the isolation and identification of three new compounds from the rare class of 22-membered macrolactone polyketides, named chaxalactins A-C (1-3). In addition, the known compounds deferroxamine E (4), hygromycin A (5), and 5 ''-dihydro-hygromycin A (6) were detected. The isolated compounds were characterized by NMR spectroscopy and accurate mass spectrometric analysis. Compounds 1-3 displayed strong activity against Gram-positive but weak activity Gram-negative strains tested.
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