Journal
JOURNAL OF NATURAL PRODUCTS
Volume 74, Issue 9, Pages 1996-2000Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np100902f
Keywords
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Funding
- National Science Council, Taiwan, ROC
- Taiwan Department of Health Clinical Trial and Research Center of Excellence [DOH 100-TD-B-11-004]
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In order to explore the anti-inflammatory principles of the mycelia of Cordyceps sinensis, the crude extract and partially purified fractions were examined for their inhibition of superoxide anion generation and elastase release. Further chemical investigation of the bioactive fractions has resulted in the identification of 50 compounds, including five constituents, cordysinins A-E (1-5), reported from a natural source for the first time. In addition, compounds were examined for their anti-inflammatory activity. 1-(5-Hydroxymethyl-2-furyl)-beta-carboline displayed the most significant inhibition of superoxide anion generation and elastase release with IC50 values of 0.45 +/- 0.15 and 1.68 +/- 0.32 mu M, respectively.
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