Journal
JOURNAL OF NATURAL PRODUCTS
Volume 75, Issue 1, Pages 60-66Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np200611f
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Funding
- NIH [NS 053398, ICBG FIC TW006634]
- FOGARTY INTERNATIONAL CENTER [U01TW006634] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS053398] Funding Source: NIH RePORTER
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Credneramides A (1) and B (2), two vinyl chloride-containing metabolites, were isolated from a Papua New Guinea collection of cf. Trichodesmium sp. nov. and expand a recently described class of vinyl chloride-containing natural products. The precursor fatty acid, credneric acid (3), was isolated from both the aqueous and organic fractions of the parent fraction as well as from another geographically and phylogenetically distinct cyanobacterial collection (Panama). Credneramides A and B inhibited spontaneous calcium oscillations in murine cerebrocortical neurons at low micro-molar concentrations (1, IC50 4.0 mu M; 2, IC50 3.8 mu M).
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