Journal
JOURNAL OF NATURAL PRODUCTS
Volume 74, Issue 10, Pages 2122-2127Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np200399t
Keywords
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Funding
- Chinese Academy of Sciences [KSCX2-YW-G-065, KZCX2-YW-JC202, LYQY200805, SQ201015, KZCX2-EW-G-12, 08SL111001]
- National Natural Science Foundation of China for Young Scholars [31000051]
- Science and Technology Planning Project of Guangdong Province [2010B030600010]
- National Basic Research Program of China [2010CB833805]
- Scientific Research Foundation for the Returned Overseas Chinese Scholars of the State Education Ministry
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Four new beta-carboline alkaloids, designated marinacarbolines A D (1-4), two new indolactam alkaloids, 13-N-demethyl-methylpendolmycin (5) and methylpendolmy-cin-14-O-alpha-glucoside (6), and the three known compounds 1-acetyl-beta-carboline (7), methylpendolmycin (8), and pendolmycin (9) were obtained from the fermentation broth of Marinactinospora thermotolerans SCSIO 00652, a new actinomycete belonging to the family Nocardiopsaceae. Their structures were elucidated by extensive MS and ID and 2D NMR spectroscopic data analyses. The structure of compound I was further confirmed by single-crystal X-ray crystallography. The new compounds 1-6 were inactive against a panel of eight tumor cell lines (IC50 > 50 mu M) but exhibited antiplasmodial activities against Plasmodium falciparum lines 3D7 and Dd2, with IC50 values ranging from 1.92 to 36.03 mu M.
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