Journal
JOURNAL OF NATURAL PRODUCTS
Volume 74, Issue 2, Pages 169-174Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np100541a
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Funding
- Ministry of Education [97C031702]
- National Science Council of Taiwan [NSC 98-2113-M-110-002-MY3]
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Four new nardosinane-type sesquiterpenoids, flavalins A-D (1-4), have been isolated from the Formosan soft coral Lemnalia flava. The structures of the new metabolites were determined by extensive spectroscopic analysis, and the structure of 2 was confirmed by X-ray diffraction analysis. A plausible biosynthetic pathway to 1 and 2 is proposed. Compound 1 was found to display dose-dependent inhibition of iNOS protein expression, and 1 and 2 Were shown to possess significant neuroprotective activity.
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