Journal
JOURNAL OF NATURAL PRODUCTS
Volume 74, Issue 10, Pages 2219-2223Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np200597m
Keywords
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Funding
- National Natural Science Foundation of China [21172204, 30670219, 30770235]
- National Basic Research Program of China [2010CB833800]
- Major Program for Technique Development Research of New Drugs in China [2009ZX09103-046]
- Shandong Natural Science Foundation [ZR2009CQ030]
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Three new alpha-pyrones, nocapyrones E-G (1-3), and three new diketopiperazine derivatives, nocazines A-C (4-6), together with a new oxazoline compound, nocazoline A (7), were isolated from the marine-derived actinomycete Nocardiopsis dassonvillei HR10-5. The new structures of 1-7 were determined by spectroscopic analysis, X-ray single-crystal diffraction, CD spectra, and modified Mosher and Marfey methods. Compounds 1-3 showed modest antimicrobial activity against Bacillus subtilis with MIC values of 26, 14, and 12 mu M, respectively.
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