Journal
JOURNAL OF NATURAL PRODUCTS
Volume 74, Issue 10, Pages 2299-2303Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np2005055
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Funding
- FP7 EC Project NatPharma [REGPOT-2008-1, 229893]
- Fonds National de la Recherche Scientifique (FNRS, Belgium)
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One new (1) and three known (2-4) isonitrile diterpenes, isolated from the Caribbean sponge Pseudoaxinella flava, were assayed in human cancer cell lines in vitro using an MTT colorimetric assay and quantitative videomicroscopy. Compounds 1-4 displayed activity for human PC3 prostate apoptosis-sensitive cancer cell lines. Compounds 3 and 4 demonstrated similar growth inhibitory effects for three apoptosis-sensitive and three apoptosis-resistant cancer cell lines: Quantitative videomicroscopy analysis revealed that compounds 1 and 2 exerted their activity through cytotoxic effects, and compounds 3 and 4 through cytostatic effects. These results identify marine diterpene isonitriles as potential lead compounds for anticancer drug discovery.
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