Journal
JOURNAL OF NATURAL PRODUCTS
Volume 74, Issue 8, Pages 1751-1756Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np200258h
Keywords
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Funding
- National Basic Research Program of China [2010CB833800]
- National Natural Science Foundation of China [30973680, 30670219, 31070045]
- Special Fund for Marine Scientific Research in the Public Interest of China [2010418022-3]
- PCSIRT [IRT0944]
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Five new bipyridine alkaloids (1-5) and a new phenylpyridine alkaloid (6), which we name caerulomycins F-K, along with five known analogues (7-11), were isolated from the marine-derived actinomycete Actinoalloteichus cyanogriseus WH1-2216-6. The structures of 1-6 were established on the basis of spectroscopic analyses and chemical methods. Compounds 1-10 showed cytotoxicity against the HL-60, K562, KB, and A549 cell lines, with IC50 values of 0.26 to 15.7 mu M. Compounds 7 and 8 also showed antimicrobial activities against Escherichia coli, Aerobacter aerogenes, Pseudomonas aeruginosa, and Candida albicans, with MIC values of 9.7 to 38.6 mu M.
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