Journal
JOURNAL OF NATURAL PRODUCTS
Volume 74, Issue 1, Pages 32-37Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np100568w
Keywords
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Funding
- National Natural Science Foundation of China [30925039]
- Ministry of Science and Technology of China [2009CB522302, 2008ZX09401-05, 2009ZX09302-004]
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New N-hydroxypyridones, militarinones E (1) and F (2), phenylhydrazones, farylhydrazones A (3) and B (4), a quinazolinone, 2-(4-hydroxybenzyl)quinazolin-4(3H)-one (5), and the known militarinones A (6) and B (7) were isolated from cultures of the Cordyceps-colonizing fungus Isaria farinosa. The structures of 1-5 were elucidated by spectroscopic methods, and 3 was confirmed by X-ray crystallography. The absolute configuration of the C-4' secondary alcohol in 1 was deduced via the circular dichroism data of the in situ formed [Rh-2(OCOCF3)(4)] complex. Compounds 1 and 6 showed significant cytotoxicity against A549 cells, whereas 7 was active against Staphylococcus aureus, Streptococcus pneumoniae, and Candida albicans.
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