Journal
JOURNAL OF NATURAL PRODUCTS
Volume 74, Issue 7, Pages 1597-1605Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np2002226
Keywords
-
Funding
- NCI/NIH [PO1 CA125066]
Ask authors/readers for more resources
Four cyclic decapeptides, minutissamides A-D (1-4), were isolated from the cultured cyanobacterium Anabaena minutissima (UTEX 1613). The planar structures were determined using various spectroscopic techniques including HRESIMS and 1D and 2D NMR experiments. The absolute configurations of the alpha-amino acid residues were assigned using Marfey's method after acid hydrolysis. The absolute configuration of a beta-amino acid residue was assigned by a combination of the advanced Marfey's method, J-based configurational analysis, and ROE spectroscopic analysis. The structures of minutissamides A-D (1-4) were characterized by the presence of three nonstandard a-amino acid residues (two alpha,beta-dehydro-alpha-aminobutyric acids and one N-methylated Asn) and one beta-amino acid residue (2-hydroxy-3-amino-4-methyldodecanoic acid or 2-hydroxy-3-amino-4-methylhexadecanoic acid). Minutissamides A-D (1-4) exhibited antiproliferative activity against the HT-29 human colon cancer cell line with IC50 values of 2.0, 20.0, 11.8, and 22.7 mu M, respectively.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available