Journal
JOURNAL OF NATURAL PRODUCTS
Volume 74, Issue 10, Pages 2278-2281Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np200365z
Keywords
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Funding
- Major State Basic Research Development Program [2009CB125905]
- National Natural Science Foundation of China [30870083, 31070051]
- Department of Science and Technology of Yunnan Province [2008CD068, 2010GA011]
- Scientific Research Foundation for the Returned Overseas Chinese Scholars
- State Education Ministry [[2009]1341]
- Young Academic and Technical Leader Raising Foundation of Yunnan Province [2009CI051]
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Six indole alkaloids with various levels of prenylation were isolated from the thermophilic fungus Talaromyces thermophilus strain YM3-4. Their structures were identified by NMR and MS spectroscopic analyses. Compounds 1 and 2 are new analogues of the key versatile precursor notoamide E. Compound 3 is a novel analogue of preechinulin, and compound 4 was reported as a natural occurring cyclo(glycyltryptophyl) for the first time. The metabolite profile of this thermophilic organism displayed a biosynthetic pathway for talathermophilins.
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