Journal
JOURNAL OF NATURAL PRODUCTS
Volume 74, Issue 5, Pages 1093-1099Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np200033y
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Funding
- Canadian Cancer Society
- Aquinox Pharmaceuticals
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Two new cyclic depsipeptides, turnagainolides A (1) and B (2), have been isolated from laboratory cultures of a marine isolate of Bacillus sp. The structures of 1 and 2, which are simply epimers at the site of macrolactonization, were elucidated by analysis of NMR data and chemical degradation. A total synthesis of the turnagainolides confirmed their structures. Turnagainolide B (2) showed activity in a SHIP1 activation assay.
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