Journal
JOURNAL OF NATURAL PRODUCTS
Volume 74, Issue 10, Pages 2269-2272Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np200260f
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Funding
- CNPq
- FINEP
- MCT (IMSEAR, Institutos do Milenio)
- RENORBIO
- FAPESB
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The antimalarial activities of physalins B, D, F, and G (1-4), isolated from Physalis angulata, were investigated. In silico analysis using the similarity ensemble approach (SEA) database predicted the antimalarial activity of each of these compounds, which were shown using an in vitro assay against Plasmodium falciparum. However, treatment of P. berghei-infected mice with 3 increased parasitemia levels and mortality, whereas treatment with 2 was protective, causing a parasitemia reduction and a delay in mortality in P. berghei-infected mice. The exacerbation of in vivo infection by treatment with 3 is probably due to its potent immunosuppressive activity, which is not evident for 2.
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