Journal
JOURNAL OF NATURAL PRODUCTS
Volume 74, Issue 8, Pages 1792-1797Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np200397g
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Funding
- National Research Foundation of Korea [20090400000, 20090083538]
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Four new amino acid derivatives, herdmanines A-D (1-4), were isolated from the marine ascidian Herdmania momus. Herdmanines A-C contain the unusual D-form of arginine. Compounds 3 and 4 had a moderate suppressive effect on the production of NO, with IC50 values of 96 and 9 mu M, respectively. These compounds were found to inhibit the mRNA expression of iNOS. The inhibitory activities on the production and mRNA expression of pro-inflammatory cytokines such as TNF-alpha, IL-1 beta, and IL-6 were evaluated.
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