Journal
JOURNAL OF NATURAL PRODUCTS
Volume 74, Issue 4, Pages 776-781Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np100840w
Keywords
-
Funding
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
- Biota Instituto Virtual da Biodiversidade [03/02176-7]
Ask authors/readers for more resources
Four new clerodane diterpenes, casearupestrins A-D (1-4), were isolated from the leaves of Casearia rupestris. Compounds 1 and 4 were acetylated to yield 2,7-di-O-acetylcasearupestrin A (5) and 2,6-di-O-acetylcasearupestrin D (6), All compounds were evaluated for cytotoxicity against a small panel of human cancer cell lines. Caseartipestrin A (1) exhibited the most potent activity against MDA/MB-435 (human Melanoma) and SF-295 (human glioblastoma) cells, superior to that of the standard drug:doxorubicin.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
