Journal
JOURNAL OF NATURAL PRODUCTS
Volume 74, Issue 5, Pages 1298-1302Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np1008976
Keywords
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Funding
- National Basic Research Program of China [2010CB833800]
- National Natural Science Foundation of China [30973680, 30670219]
- Special Fund for Marine Scientific Research in the Public Interest of China [2010418022-3]
- PCSIRT [IRT0944]
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Five new cerebrosides, chrysogesides A-E (1-5), and two new 2-pyridone alkaloids, chrysogedones A and B (6 and 7), were isolated from the fermentation broth of Penicillium chrysogenum PXP-55, a halotolerant fungus grown in a hypersaline medium. Among them, chrysogesides B-D (2-4) are the first cerebrosides that contain an unsaturated C-19-fatty acid. Their structures were identified by spectroscopic and chemical methods, including CD spectroscopy as well as the modified Mosher's method. Compound 2 showed antimicrobial activity against Enterobacter aerogenes with an MIC value of 1.72 mu M.
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