Journal
JOURNAL OF NATURAL PRODUCTS
Volume 74, Issue 2, Pages 279-282Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np1006247
Keywords
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Funding
- CNPq (Conselho Nacional de Desenvolvimento Cientifico e Tecnologico)
- CAPES (Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior)
- FAPERJ (Fundacao de Amparo a Pesquisa do Estado do Rio de Janeiro)
- CENPES-Petrobras
- FAPESP [05/60175-2]
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [05/60175-2] Funding Source: FAPESP
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Oroidin was isolated from the marine sponge Agelas sventres and inhibited the activity and function of Pdr5p, an enzyme responsible for the multidrug resistance phenotype in Saccharomyces cerevisiae. This compound may help in the development of new drugs that reverse this dangerous phenotype of pathogenic yeast and fungi.
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