Journal
JOURNAL OF NATURAL PRODUCTS
Volume 75, Issue 1, Pages 111-114Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np200740e
Keywords
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Funding
- MEXT [23102007]
- Grants-in-Aid for Scientific Research [23102007] Funding Source: KAKEN
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Seven gliotoxin-related compounds were isolated from the fungus Penicillium sp. strain JMF034, obtained from deep sea sediments of Suruga Bay, Japan. These included two new metabolites, bis(dethio)-10a-methylthio-3a-deoxy-3,3a-didehydrogliotoxin (1) and 6-deoxy-5a,6-didehydrogliotoxin (2), and five known metabolites (3-7). The structures of the new compounds were elucidated by analysis of spectroscopic data and the application of the modified Mosher's analysis. All of the compounds exhibited cytotoxic activity, whereas compounds containing a disulfide bond showed potent inhibitory activity against histone methyltransferase (HMT) G9a. None of them inhibited HMT SET7/9.
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