Journal
JOURNAL OF NATURAL PRODUCTS
Volume 74, Issue 6, Pages 1535-1538Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np200362q
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Funding
- National Institute of Environmental Health Sciences (NIEHS) [S11 ES11181]
- Hollings Marine Laboratory NMR Facility
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Pahayokolides A (1) and B (2) are cyclic undecapeptides that were isolated from the cyanobacterium Lyngbya sp. They contain the unusual alpha-hydroxy-beta-amino acid 3-amino-2,5,7,8-tetrahydroxy-10-methylundecanoic acid (Athmu). The absolute configurations of the amino acids of the pahayokolides, except for the four oxygen-bearing stereocenters of Athmu, have been determined by Marphy's method. Incorporation of labeled leucine and acetate precursors into the pahayokolides has established that Athmu is derived from a leucine or alpha-keto isocaproic acid starter unit, which is further extended with three acetate units.
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