Journal
JOURNAL OF NATURAL PRODUCTS
Volume 74, Issue 6, Pages 1508-1512Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np200058c
Keywords
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Funding
- Young Academic and Technical Leader Raising Foundation of Yunnan Province [2008PY066]
- State Key Laboratory of Phytochemistry and Plant Resources in West China [P2010-ZZ02]
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Investigation of whole plants of Euphorbia fischeriana afforded three new tigliane-diterpenoid glycosides, fischerosides A-C (1-3), together with 11 known diterpenoids. Fischerosides A-C (1-3) are the first tigliane-type diterpenoid glucosides. Their structures were determined by a combination of 1D and 2D NMR, MS, and acid hydrolysis. Inhibitory activity against HIV-1 was assessed for compounds 1-5. The new compound 3 showed an EC(50) value of 0.02 mu M and a therapeutic index (TI) of 17.50, while prostratin (4) and 12-deoxyphorbol-13,20-diacetate (5) showed significantly greater anti-HIV-1 activity.
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