Journal
JOURNAL OF NATURAL PRODUCTS
Volume 74, Issue 5, Pages 997-1002Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np100889v
Keywords
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Funding
- National Natural Science Foundation of China [20772162, 20972197]
- 863 Foundation of China [2006AA09Z422, 2007AA09Z448]
- Natural Science Foundation of Guangdong Province of China [9151027501000055]
- Science & Technology Plan Project of Guangdong Province of China [2010B030600004]
- Fundamental Research Funds for the Central Universities of China [11lgjc01]
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Eight secondary metabolites, including three new azaphilones (chermesinones A-C, 1-3), three new p-terphenyls (6'-O-desmethylterphenyllin, 4; 3-hydroxy-6'-O-desmethylterphenyllin, 5; 3 ''-deoxy-6'-O-desmethylcandidusin B, 7), and two known p-terphenyls (6, 8), were isolated from the culture of the mangrove endophytic fungus Penicillium chermesinum (ZH4-E2). Their structures were established by spectroscopic analysis. The absolute configuration of 1 was determined by X-ray crystallography. Terphenyls 4, 5, and 6 exhibited strong inhibitory effects against alpha-glucosidase with IC50 values of 0.9, 4.9, and 2.5 mu M, respectively. Terphenyls 7 and 8 showed inhibitory activity toward acetylcholinesterase with IC50 values of 7.8 and 5.2 mu M.
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