Journal
JOURNAL OF NATURAL PRODUCTS
Volume 74, Issue 7, Pages 1645-1649Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np200108h
Keywords
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Funding
- Japan Society for the Promotion of Science (JSPS)
- Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan [S0801043]
- Japan Science Society [22-308]
- Grants-in-Aid for Scientific Research [22790173] Funding Source: KAKEN
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Three new diterpenes, myrocin D (1), libertellenone E (2), and libertellenone F (3), and a new isocoumarin, decarboxyhydroxycitrinone (4), were isolated from the marine fungus Arthrinium sacchari, together with three known compounds (5-7). The structures of 1-4 were elucidated from spectroscopic data (NMR, MS, IR), and the absolute configurations of 1-3 were determined by X-ray diffraction analysis. The antiangiogenic activity of these compounds was evaluated by measuring their antiproliferation effects on human umbilical vein endothelial cells (HUVECs) and human umbilical artery endothelial cells (HUAECs). Compounds 4-7 showed inhibitory activity.
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