Journal
JOURNAL OF NATURAL PRODUCTS
Volume 74, Issue 5, Pages 1275-1280Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np1006795
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Funding
- NIH, National Cancer Institute, Center for Cancer Research
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Lithothamnin A (1) is a new bastadin-like metabolite and represents the first report of this class of molecules from the red alga Lithothamnion fragilissimum. Lithothamnin A contains several novel structural features that distinguish it from other bastadins. These unique structural features include novel aromatic substitution patterns and the presence of a meta-meta linkage between aromatic rings, in addition to the meta-para linkage seen in the bastadins. Lithothamnin A is modestly cytotoxic in a panel of six human tumor cell lines.
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