Journal
JOURNAL OF NATURAL PRODUCTS
Volume 74, Issue 5, Pages 1009-1014Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np100900k
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Funding
- Chinese National Science & Technology Pillar Program [2007BAI27B06]
- Chinese National S&T Special Project on Major New Drug Innovation [2009ZX09301-003, 2011ZX09307-002-01]
- Research Institute of Bioscience & Biotechnology, Kangwon National University
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Four new megastigmane glycosides, named gusanlungionosides A-D (1-4), together with 10 known compounds (5-14), were isolated from the stems of Arcangelisia gusanlung. The structures and absolute configurations of 1-4 were elucidated by comprehensive analysis of their NMR and CD data. Compounds 1-4 exhibited strong inhibitory effects not only on the mushroom tyrosinase activity in vitro but also on melanogenesis in cells.
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