Grandilodines A-C, Biologically Active Indole Alkaloids from Kopsia grandifolia

Three new indole alkaloids (1-3), named grandilodines A C, and five known ones were obtained from the Malayan Kopsia grandifolia. The structures were established using NMR and MS analyses and, in the case of 1 and 2, were confirmed by X-ray diffraction analyses. Alkaloids 1, 3, and lapidilectine B (8) were found to reverse multidrug resistance in vincristine-resistant KB cells.