Journal
JOURNAL OF NATURAL PRODUCTS
Volume 74, Issue 4, Pages 857-861Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np100775a
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Funding
- NSF [CHE-0130835]
- NSF CRIF MU [CHE-0639199]
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Exploration of a soft Coral (Briareum sp.) from Vanuatu led to the isolation Of three new briaranes, designated brialalepolidei A(1), B (2), and C (3). Compounds 2 and 3 reduced the expression of COX-2 inhuman colon adenocarcinoma cells, as Well as in murine macrophage cells. This is significant because the metabolic products of COX-2 have been implicated in the pathogenesis of colon cancer and other diseases.
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