Journal
JOURNAL OF NATURAL PRODUCTS
Volume 73, Issue 8, Pages 1444-1447Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np100312f
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Funding
- Ministry of Science, Economic Affaires and Transport of the State of Schleswig-Holstein (Germany)
- European Union (EFRE)
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Four new gamma-pyrones, nocapyrones A-D (1-4), were isolated from an organic extract of the Nocardiopsis strain HB383, which was isolated from the marine sponge Halichondria panicea. These are the first gamma-pyrones reported from a Nocardiopsis strain. The structures were elucidated on the basis of one- and two-dimensional NMR experiments and supported by HPLC-UV/MS and HRESIMS analyses. The biosynthesis of nocapyrone A was investigated by feeding experiments with (13)C-labeled compounds. In addition, one dikeopiperazine, which was only known as a synthetic compound before, was isolated. The bioactivies of 1, 2, and the diketopiperazine were evaluated in a panel of assays.
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