Journal
JOURNAL OF NATURAL PRODUCTS
Volume 73, Issue 2, Pages 221-225Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np900849y
Keywords
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Funding
- NSFC [20802082, 30830115]
- Chinese Academy of Sciences [KSCX1-YW-R-24]
- Major State Basic Research Development program of China [2009CB522303, 2009CB940900]
- Young Academic and Technical Leader Rising Foundation of Yunnan province [2006PY0147]
- Natural Science Foundation of Yunnan Province [2005XY04, 2006B0042Q]
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Six new nortriterpenoids, schirubridilactones A-F (1-6). as well as 14 known compounds, were isolated from the leaves and stems of Schisandra rubriflora. The Structures of 1-6 were elucidated oil the basis of spectroscopic methods including HSQC, HMBC, H-1-H-1 COSY, and ROESY NMR experiments. The relative stereochemistry of I was confirmed through single-crystal X-ray analysis. In addition, compounds 1-6 showed anti-HIV-1 activity with EC50 values in the range 14.3-80.8 mu g/mL and Selectivity indices in the range 2.2-9.0.
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