Journal
JOURNAL OF NATURAL PRODUCTS
Volume 73, Issue 11, Pages 1884-1890Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np1005357
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Funding
- DSF-IRD (BST) from France
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Three new caffeic acid esters (1-3), four new lignans (4-7), and the known compounds (7'S)-parabenzlactone (8), dihydrocubebin (9), and justiflorinol (10) have been isolated from leaves of Piper sanguineispicum. Their structures were determined by spectroscopic methods, including 1D and 2D NMR, HRCIMS, CD experiments, and chemical methods. Compounds 1-10 were assessed for their antileishmanial potential against axenic amastigote forms of Leishmania amazonensis. Caffeic acid esters 1 and 3 exhibited the best antileishmanial activity (IC50 2.0 and 1.8 mu M, respectively) with moderate cytotoxicity on murine macrophages.
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