Journal
JOURNAL OF NATURAL PRODUCTS
Volume 73, Issue 10, Pages 1730-1733Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np1005086
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Funding
- ICSN-CNRS
- Agence Universitaire de la Francophonie (AUF)
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In a screening program directed to the discovery of new anticancer agents from Madagascan plants, ethyl acetate extracts of Crown barorum and C. goudotii showed strong cytotoxic activity, with 100% inhibition at 10 mu g/mL in a primary screen using the murine lymphocytic leukemia P388 cell line. Bioassay-guided fractionation led to the isolation of two new 3,4-seco-atisane diterpenoids, crotobarin (1) and crotogoudin (2). Their structures were elucidated by spectroscopic data interpretation. Compounds 1 and 2 produced a net progression in the number of cells arrested at the G2/M growth stage in the cell cycle of the K562 human leukemia cell line at 4 mu M.
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