Journal
JOURNAL OF NATURAL PRODUCTS
Volume 73, Issue 10, Pages 1723-1726Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np100426j
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Funding
- NCET Foundation
- NSFC [30725045]
- Ministry of Science and Technology, China [2009ZX09311-001, 2008ZX09308-005]
- Shanghai Leading Academic Discipline Project [B906]
- Scientific Foundation of Shanghai China [09DZ1975700, 09DZ1971500]
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The structures of 1,5-dihydroxy-3,8-epoxyvalechlorine (1a) and volvaltrate B (6a), two new chlorinated iridoids isolated from Valeriana jatamansi and V. officinalis, respectively, were originally assigned on the basis of spectroscopic methods. Reinvestigation using X-ray analysis and chemical transformation revealed that the original assignment of H-7 in la and OH-8 in 6a should be inverted and that the structures should be revised to 1 and 6, respectively. Correspondingly, the structure of valeriotetrate C (7a) should be revised to 7. Volvaltrate B (6) showed cytotoxic activity against the lung adenocarcinoma (A549), metastatic prostate cancer (PC-3M), colon cancer (HCT-8), and hepatoma (Be17402) cell lines, with IC50 values of 8.5, 2.0, 3.2, and 6.1 mu M, respectively.
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