Journal
JOURNAL OF NATURAL PRODUCTS
Volume 73, Issue 11, Pages 1821-1832Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np100470h
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Funding
- FAPESP as BIOTA/BIOprospecTA [05/60175-2, 06/61693-0]
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [05/60175-2] Funding Source: FAPESP
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A fractional factorial design approach has been used to enhance secondary metabolite production by two Penicillium strains. The method was initially used to improve the production of bioactive extracts as a whole and subsequently to optimize the production of particular bioactive metabolites. Enhancements of over 500% in secondary metabolite production were observed for both P. oxalicum and P. citrinum. Two new alkaloids, citrinalins A (5) and B (6), were isolated and identified from P. citrinum cultures optimized for production of minor metabolites.
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