Journal
JOURNAL OF NATURAL PRODUCTS
Volume 73, Issue 11, Pages 1963-1966Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np100506z
Keywords
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Funding
- NOAA OHHI [NA04OAR4600206]
- NSF [OCE 04-32479, OCE 09-11000]
- NIEHS [ES P50 ES012740]
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Extracts of a marine Pseudoalteromonas sp. (CMMED 290) isolated from the surface of a nudibranch collected in Kaneohe Bay, Oahu, displayed significant antimicrobial activity against methicillin-resistant Staphylococcus aureus. Bioassay-guided fractionation of the lipophilic extract led to the isolation and structure elucidation of two new highly brominated compounds, 2,3,.5,7-tetrabromobenzofuro[3,2-b]pyrrole (1) and 4,4',6-tribromo-2,2'-biphenol (2). In addition, we have identified the known compounds pentabromopseudilin and bromophene. We describe the isolation and structure elucidation of the compounds 1 and 2 together with their antimicrobial activities against methicillin-resistant Staphylococcus aureus.
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