Antiviral and Anti-inflammatory Diterpenoids from the Soft Coral Sinularia gyrosa

Chemical investigation of the salt coral Sinularia gyrosa led to the purification of three new diterpenoids. designated as gyrosanols A-C (1-3). The structures of 1-3 were elucidated through extensive spectroscopic analyses. Compounds 1 and 2 exhibited antiviral activity against HCMV with IC(50)'s of 2.6 and 3.7 mu M, respectively. In addition, compounds 1 and 2 showed significant anti-inflammatory activity by reducing the levels of the COX-2 protein (19.6 +/- 3.9% and 29.1 +/- 9.6%, respectively) in RAW 264.7 macrophages.